diff --git a/build.psm1 b/build.psm1
index afba567d227..43485ca8463 100644
--- a/build.psm1
+++ b/build.psm1
@@ -391,6 +391,13 @@ Fix steps:
         $Arguments += "/property:IsWindows=false"
     }
 
+    # Framework Dependent builds do not support ReadyToRun as it needs a specific runtime to optimize for.
+    # The property is set in Powershell.Common.props file.
+    # We override the property through the build command line.
+    if($Options.Runtime -like 'fxdependent*') {
+        $Arguments += "/property:PublishReadyToRun=false"
+    }
+
     $Arguments += "--configuration", $Options.Configuration
     $Arguments += "--framework", $Options.Framework