I'm using python-patch in one of my projects, so to return the favor here are 
my changes:

1. Support -p<num> like GNU patch, to strip path components

2. Set exit code to 0 or 1 depending on errors occured (like GNU patch)

3. Support creating new files (source=/dev/null), like GNU patch

4. Don't touch global logging configuration on module load, unless used as 
__main__  (useful when embedding in a larger project)

A patch is attached (applies cleanly to SVN r111)