Comments for Ferniglab Blog

Comment on Some thoughts on SARS-CoV-2 and heparan sulfate by ferniglab

ferniglab — Wed, 23 Mar 2022 21:24:19 +0000

Will take me some time to wade through the links and read, but will get back to you.

Comment on Some thoughts on SARS-CoV-2 and heparan sulfate by Ryan Ferris

Ryan Ferris — Wed, 23 Mar 2022 21:20:27 +0000

Just an “immune hacker” and Long Covid survivor. Saw your twitter reply (https://twitter.com/DaveFernig/status/1505276683435270147) and decided to ask some pesky layman like questions (# Question … ). I am rather fixated on EGCG since I have found much improvement in my Long Covid symptoms after beginning use of it. There seems to be a relationship between EGCG and heparin.

# What is “Enriched Heparin” in this SC2 clinical trial:
“Enriched Heparin Anti COVID-19 Trial (EnHanCed)”
https://clinicaltrials.gov/ct2/show/record/NCT04743011

#Has Enoxaparin and other low molecular weight heparin (LMWH) been studied enough as therapeutics for COVID-19?

“Enoxaparin is associated with lower rates of mortality than unfractionated Heparin in hospitalized COVID-19 patients”
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00054-7/fulltext

“Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on Mortality”
https://pubmed.ncbi.nlm.nih.gov/33186991/

#Can components of EGCG be used with heparin or heparin related molecules to battle coagulation found in Long Covid, Covid, Vax AEs?

“Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102129/

“A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans”
https://journals.asm.org/doi/10.1128/JVI.00896-14

“Interaction between the Carboxyl-terminal Heparin-binding Domain of Fibronectin and (−)-Epigallocatechin Gallate”
https://pubag.nal.usda.gov/catalog/6917420

“Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry”
https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.24803

“Antiviral Effect of Epigallocatechin Gallate via Impairing Porcine Circovirus Type 2 Attachment to Host Cell Receptor”
https://www.mdpi.com/1999-4915/12/2/176/htm

“Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor”
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00680-8

Comment on Predictable: mess caused by adults, blame the kids by victoriarose002

victoriarose002 — Thu, 13 Aug 2020 20:14:12 +0000

I think it is awful- especially as most of these students who have been downgraded would be from lower income households.

Comment on We’re back & rocking by Paul Free

Paul Free — Mon, 22 Jun 2020 16:01:33 +0000

It’s great to see some pictures of the lab again, I miss those days of having lunch at the end of the corridor, at the time Billy with Mates with the also former French group of colleagues such as Val, Paul and Yann, fun times for all.
Let’s hope can get a little closer to that someday soon for the current workers in Biosciences.

Comment on Responses to evidence of self-plagiarism by Graphene Flagship deploys Stripy Stellacci to fight the Coronavirus – For Better Science

Wed, 17 Jun 2020 06:01:27 +0000

[…] summed up the journal responses here, back then no editor planned to take any action. Later on there were some corrections. This was the […]

Comment on Errare humanum est sed perseverare diabolicum by Graphene Flagship deploys Stripy Stellacci to fight the Coronavirus – For Better Science

Wed, 17 Jun 2020 06:01:06 +0000

[…] at the University of Liverpool, UK. Levy was supported in his criticism by his Liverpool colleague Dave Fernig and in particular by Philip Moriarty at University of […]

Comment on The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding by Heparin inhibits SARS-cov-2 cell infectivity | Ferniglab Blog

Heparin inhibits SARS-cov-2 cell infectivity | Ferniglab Blog — Wed, 29 Apr 2020 12:45:55 +0000

[…] to determine if this is actually the case takes time. It is nearly a month since the the team’s initial preprint (now updated with low molecular weight heparins), which was the first demonstration of an […]

Comment on People by porton

porton — Wed, 13 Nov 2019 10:30:03 +0000

Hi,

Please publish a copy of this blog post:

https://blog.mathematics21.org/2019/11/05/how-to-publish-a-math-science-article-or-book-at-amazon-for-free-no-need-for-scientific-journals-anymore/

Comment on An Open Letter to my Representatives by An Open Letter to my Representatives – update | Ferniglab Blog

An Open Letter to my Representatives – update | Ferniglab Blog — Mon, 29 Jul 2019 04:32:03 +0000

[…] « An Open Letter to my Representatives […]

Comment on Workload Management Schemes by ferniglab

ferniglab — Wed, 03 Apr 2019 19:46:14 +0000

In reply to Clement Cohen.

Hi Clement, long time no see, didn’t know you were lurking there in the background :).

It is perhaps more complex in our case, in that there is such a variety of outputs, which are not easily comparable, and all of which will be describing someone new to humanity – an issue that arises, but probably shouldn’t, is how ‘new’ or how ‘important’ the work is. The reason it is false to try to qualify the discovery is that only time can really tell. In defence of universities, such face-to-face meetings occur, and have done so for a very long time. Workload schemes have been placed on top of such face-to-face meetings. To add a little dash of cynicism, from someone who works extensively with the private sector, workload schemes have a smell of something thought up in the public sector because they feel it looks like it is what might happen in the private sector (note my comment on ‘super managers’). It doesn’t, as we both know!