Flindr – first in class small molecule targeted therapeutics

The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens

ivan — Tue, 04 Jun 2024 09:32:55 +0000

The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens

D W Vredevoogd, G Apriamashvili, D S Peeper

Immunooncol Technol. 2021 Oct 28:11:100043. doi: 10.1016/j.iotech.2021.100043. eCollection 2021 Oct.

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

ivan — Tue, 04 Jun 2024 09:32:11 +0000

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

Georgi Apriamashvili, David W Vredevoogd, Oscar Krijgsman, Onno B Bleijerveld, Maarten A Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J H Traets, Daniela D’Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L Visser, James D Londino, Rebekah Sanchez-Hodge, Leah E Oswalt, Selin Altinok, Jonathan C Schisler, Maarten Altelaar, Daniel S Peeper

Nat Commu. 2022 Apr 8;13(1):1923. doi: 10.1038/s41467-022-29442-x.

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

ivan — Tue, 04 Jun 2024 09:31:25 +0000

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

Chun-Pu Lin, Pierre L Levy, Astrid Alflen, Georgi Apriamashvili, Maarten A Ligtenberg, David W Vredevoogd, Onno B Bleijerveld, Ferhat Alkan, Yuval Malka, Liesbeth Hoekman, Ettai Markovits, Austin George, Joleen J H Traets, Oscar Krijgsman, Alex van Vliet, Joanna Poźniak, Carlos Ariel Pulido-Vicuña, Beaunelle de Bruijn, Susan E van Hal-van Veen, Julia Boshuizen, Pim W van der Helm, Judit Díaz-Gómez, Hamdy Warda, Leonie M Behrens, Paula Mardesic, Bilal Dehni, Nils L Visser, Jean-Christophe Marine, Gal Markel, William J Faller, Maarten Altelaar, Reuven Agami, Michal J Besser, Daniel S Peeper

Cancer Cell. 2024 Mar 13:S1535-6108(24)00060-6. doi: 10.1016/j.ccell.2024.02.016. Online ahead of print.

CANCER IMMUNOLOGY. The “cancer immunogram”

ivan — Tue, 04 Jun 2024 09:30:47 +0000

CANCER IMMUNOLOGY. The “cancer immunogram”

Christian U Blank , John B Haanen , Antoni Ribas , Ton N Schumacher

Science. 2016 May 6;352(6286):658-60. doi: 10.1126/science.aaf2834.

Flindr finds $21M to progress precision medicine pipeline for cancer

ivan — Tue, 04 Jun 2024 09:27:19 +0000

Flindr finds $21M to progress precision medicine pipeline for cancer

Venture report: Arch, Foresite $1B AI play Xaira starting with Baker lab’s de novo biologics. Plus rounds for Rubedo, Flindr, Endeavor, SynOx and more

ivan — Tue, 04 Jun 2024 09:26:54 +0000

Venture report: Arch, Foresite $1B AI play Xaira starting with Baker lab’s de novo biologics. Plus rounds for Rubedo, Flindr, Endeavor, SynOx and more

Belgen stoppen mee 20 miljoen euro in Nederlandse kankerspecialist

ivan — Tue, 04 Jun 2024 09:26:02 +0000

Belgen stoppen mee 20 miljoen euro in Nederlandse kankerspecialist

Dutch biotech attracts J&J support for cancer pipeline in $21M Series A

ivan — Tue, 04 Jun 2024 09:24:56 +0000

Dutch biotech attracts J&J support for cancer pipeline in $21M Series A

Flindr’s $21.4M series A advances immune modulators

ivan — Tue, 04 Jun 2024 09:23:44 +0000

Flindr’s $21.4M series A advances immune modulators

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

piomat — Fri, 17 May 2024 07:04:45 +0000

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

Lynn Elton, Isabelle Carpentier, Jens Staal, Yasmine Driege, Mira Haegman, Rudi Beyaert

FEBS J . 2016 Feb;283(3):403-12. doi: 10.1111/febs.13597. Epub 2015 Nov 26.