Today Prozomix has commissioned its first solar plant (78 kW) on its manufacturing plant, this facility will generate approximately 90 mW / year and push Prozomix further towards its green ambitions and allow Prozomix to produce green enzymes from green electricity! Special thanks go to Minel Energy, Newcastle, for the design and installation of this green energy project.

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Please contact [email protected] for further information. 

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15th February 2021 – The Prozomix team have successfully embarked on its 2021 Marine Expedition of UK waters.

The Prozomix team have successfully embarked, after two days of equipment tests, on a marine expedition of UK waters for the identification of novel biodiversity for future enzyme discovery. The expedition is set to last approximately 14 days and the goal is to sequence over 1 trillion base pairs of unique UK biodiversity, which will underpin the discovery of thousands of novel biocatalysts over the coming years.

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We are pleased to announce the success of an application for a 4-year BBSRC iCASE Award, applied for by Northumbria University in conjunction with Prozomix, focussed on novel biocatalytic routes towards volatile sulphur compounds (VSCs).

The following is a full description of the project, as can be found on FindAPhD.com (www.findaphd.com/search/ProjectDetails.aspx):

We are pleased to invite applications for a 4 year-BBSRC Industrial CASE PhD Studentship based at Northumbria University Newcastle and in collaboration with Prozomix Ltd. 

The studentship will commence in October 2015. 

In this fully-funded 4-year BBSRC ICASE project, we aim to develop a novel biocatalytic approach for the manufacturing of enantiomerically pure volatile sulphur compounds (VSCs). Foods and beverages contain, generally in trace amounts, a number of different VSCs possessing a strong and powerful odour and contributing to both agreeable and disagreeable flavours and fragrances. From a chemical point of view, VSCs are often chemically labile and, as a result, their manufacture can be challenging. VSCs can exist as chiral isomers and their olfactory perception may depend on their diastereomeric and enantiomeric form. For example the (R)-enantiomer of 3-thio-1-hexanol has a tropical fruit aroma, whereas its (S)-enantiomer has a sulphureous and herbaceous smell. The stereodifferentiation of chiral VSCs has a great impact on the flavour and quality of foods and thus the identification of methods for the production of enantiomerically pure ingredients is highly desirable. 

The proposed project aims to develop a sustainable biocatalytic approach for the manufacturing of new VSCs. In particular, the PhD candidate will explore the enantioselective synthesis of mercapto-carboxylic acids and amides using nitrilase and nitrile hydratase enzymes, respectively. Novel chemoenzymatic and enzyme-enzymatic cascade approaches involving monoamine oxidases will be developed as well. 

The student will be trained in techniques pertinent to the project such as organic synthesis, enzymatic synthesis and biotransformations, NMR spectroscopy, chromatography and mass spectrometry. In addition, the PhD candidate will be trained in aspects of the discovery, development and manufacturing of novel biocatalysts in collaboration with the industrial partner, Prozomix Ltd. Regular placements at Prozomix Ltd will be incorporated as part of the project, so providing research experience in a commercial environment. 

The project is due to commence October 2015 and is open to UK/EU* nationals only due to the nature of the funding. 
*Applicants must be UK/EU nationals who have resided in the UK since at least 1 September 2012 in order to qualify for full funding. 

Applicants should hold a first or upper second class honours degree (in a relevant subject) from a British higher education institution, or equivalent. Applicants, who have a first class or 2:1 or equivalent honours degree, or MChem or MSci in organic, pharmaceutical or food chemistry subjects or biochemistry, are encouraged to apply. Experience in catalysis and biocatalysis is desirable but not mandatory. 

Informal enquiries relating to the project and/or suitability should be directed to Dr Daniele Castagnolo([email protected]) 

To apply, contact PGR Admission to request the appropriate application form, quoting the advert reference above, via email to [email protected] or by using the application link on this page. 

Please include the following with your application: 

– Academic CV 

– Official academic transcripts + a personal statement (max 2 A4 pages) outlining your career intentions and your suitability for the project 

– Contact details for two suitable referees

Funding Notes:

The 4-year full-time studentship provides full support for UK/EU tuition fees and an annual tax-free stipend at RCUK rates (currently £13,863; in addition a £2,000 per year bonus will be provided by Prozomix).

The project is open to UK/EU nations only due to the nature of the funding.

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The advantages of this new and exciting technology with respect to biocatalyst discovery are detailed here. Customers who are keenly awaiting the new catalysts should be offered their first Prozomix meta-GRASP panels by early 2015.

For further information, please contact [email protected].

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(project co-funded by)

Prozomix is pleased to announce that in collaboration with Northumbria University it has been awarded a further Technology Strategy Board Grant (Sustainable High-value Chemical Manufacture Through Industrial Biotechnology – Technical Feasibility Project “Development of Biocatalysis Tools for the Production of Cis-3-hexenol from Vegetable Oil Waste Streams”; Grant No. 131146). The project with total budget of £150 K will see the discovery of novel enzymes towards a three enzyme cascade yielding the flavour/fragrance compound cis-3-hexenol from common linseed oil. This compound is in increasing demand, yet the natural source is neither scalable or relaible, and thus a biocatalytic route could be highly lucrative. The project activities over 9 months will see feasibility established for the novel triple enzyme cascade, afterwhich interest from a commercial end-user will be sought to progress to practical application.

For further information, please contact [email protected].

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Please contact [email protected] for further information.

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We are delighted to announce a collaboration with CLEA Technologies B.V., an internationally recognised innovative leader in enzyme immobilisation and biocatalytic process development, that will combine the proven and powerful GRASP™ high-throughput novel biocatalyst development technology of Prozomix with advanced immobilisation technology. The result will be custom immobilisation services from CLEA Technologies for any enzyme (i.e. ketoreductases (KREDs) / alcohol dehydrogenases (ADHs), EREDs, P450s, nitrilases, etc) from the Prozomix range not yet available in immobilised form.

Please see here for further information, or contact [email protected].

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The other members of the KYROBIO consortium are BICT, Ingenza, CLEA Technologies, BioInfoBank Institute, VTU Technology, ACIB, University of Graz, X-Zyme, evocatal, Bio-prodict, University of Manchester, CIKTN, C-Tech Innovation, University of Groningan, University of Stuttgart, and the Technical University of Denmark.

Please contact [email protected] for further information. 

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