Here is to Spotify: Sequencing by Expansion by Roche. Also, if you think 454 is dead: get your 3D printer out and build yourself a (quite not so good) sequencing machine (some extra parts needed): https://454.bio/

We would be grateful if you could take a moment to “rate the show” on your preferred platform. Doing so will help it reach a wider audience, allowing more people to gain insights into sequencing technologies 

Let’s keep the conversation going – choose the platform where you like to listen to the episode: https://ngs-cn.de/explain-podcast/

Spotify supports chapters which makes it easier to find nuggets – check it out & rate our podcast if you’re using mobile version!

Supported by the West German Genome Center and Next Generation Sequencing Competence Network, we’re dedicated to discuss genomics & transcriptomics tech in the way YOU could understand 

Recorded at the Multimediazentrum, University of Düsseldorf

This time Kenneth Peuker from the Universität Greifswald will talk about host factors in the pathogenesis of colorectal cancer metastasis.

Colorectal cancer (CRC)-driven liver metastasis formation is one of the main drivers of cancer-related deaths. As CRC development has formerly been identified as a disease of elderly people, recent epidemiological data shows an increasing incidence of CRC in people younger than 50 years of age (early-onset colorectal cancer, EOCRC) and often diagnosed at more advanced stages, including elevated risks for recurrence and metastasis formation, including liver metastasis. To investigate this further, we used mouse models of CRC-related liver tumor formation, where young mice exhibited greater and larger liver metastases compared to older counterparts, while the formation of primary CRC was unaffected by the age of the host. Using spatial transcriptomics approaches, we therefore focus on understanding niche-dependent mechanisms in regulating liver metastasis formation.

When? 27.11.2025 at 11 CET

Where? Zoom, register here: https://rwth.zoom-x.de/meeting/register/MYefriSaRvqHkiNRuF6aEg

23rd October – Düsseldorf: Bio Data Science Evening – let’s meet!

Register HERE | on-site event

When: 23 October | Thursday | 17:00 – 19:30
Location: O.A.S.E. das Forum des Austauschs, Heinrich-Heine Universität, Düsseldorf

CASE STUDIES IN TRANSLATIONAL MULTIOMICS
David Koppstein, PhD
DKFZ, DKTK Partner Site Essen/Düsseldorf

We present a series of vignettes of how complementary -omics technologies can be applied to different problems in the clinic. We examine individual case studies in detecting novel compound heterozygous mutations with long read sequencing, studying a chronic active EBV patient with single-cell sequencing, as well as cohort-level multiomic studies applied to uveal melanoma and B-cell precursor acute lymphoblastic leukemia.

Organized by the West German Genome Center (WGGC) Düsseldorf as a part of the Next Generation Sequencing Competence Network (NGS-CN). Supported by the Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen (MKW.NRW)

If you missed the Summer School on Spatial Transcriptomics this is your chance to catch up and learn from our experts.

Here, Maximilian Krause from the DRESDEN-concept Genome Center, one of our competence centers, gives us an overview on available sequencing techniques as of today.

And…subscribe to our NGS-CN YouTube Channel to stay tuned for the upcoming content or check out all other available videos from our webinars and last years Summer School!

https://www.youtube.com/@NGS-CN

Unraveling the Cellular Complexity of Polyneuropathies with a Multi-Omics Approach

Polyneuropathies (PNPs) are among the most common neurological disorders, leading to progressive motor and sensory impairment. Their exact causes are diverse and often remain unclear. However, identifying the underlying cause and understanding disease mechanisms is crucial—particularly for treatable forms such as immune-mediated neuropathies.

To address this, we applied a multi-omics approach combining single-nucleus RNA sequencing, spatial transcriptomics, RNA in situ hybridization, immunofluorescence, and immunohistochemistry to analyze peripheral nerves from a total of 33 PNP patients and 4 controls (365,708 nuclei).

Our results revealed unexpected perineurial cell heterogeneity, loss of Schwann cells, and lipid-associated macrophage accumulation in the nerve of patients with PNPs. These changes extend beyond the endoneurium, redefining PNP as a “pan-nerve disease” with focal perineurial hyperplasia and CXCL14 upregulation as potential molecular hallmarks.

Join our next NGS webinar | July 17th at 11:00 CEST.

Register here!

We would be grateful if you could take a moment to “rate the show” on your preferred platform. Doing so will help it reach a wider audience, allowing more people to gain insights into sequencing technologies 

Let’s keep the conversation going – choose the platform where you like to listen to the episode: https://ngs-cn.de/explain-podcast/

Spotify supports chapters which makes it easier to find nuggets – check it out & rate our podcast if you’re using mobile version!

Supported by the West German Genome Center and Next Generation Sequencing Competence Network, we’re dedicated to discuss genomics & transcriptomics tech in the way YOU could understand 

Recorded at the Multimediazentrum, University of Düsseldorf

1st July Düsseldorf: Bio Data Science Evening – let’s meet!

Register | on-site: https://forms.gle/yvEvB3HfFLDxKiYP9

Speaker?

Dr. Simon M. Zumkeller

Omics Data Research Group, Institute of Bio- and Geosciences, IBG-4: Bioinformatik, Forschungszentrum Jülich

What is the topic?

Decoding plant gene regulation with deep learning from omics data

Use the chance to meet Simon and other sequencing & bioinformatics experts on-site. Build valuable connections.

Organized by the West German Genome Center. Supported by the Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

These ecosystems are declining globally, with predictions of catastrophic coral reef loss due to human activity becoming real. Climate change raises sea temperatures, causing coral bleaching and threatening reef ecosystems. Stony corals, which form the reef’s framework, have a symbiotic relationship with microalgae and other microbes, forming a coral holobiont.

We use heat stress tests (CBASS system) across various reefs to identify thermally tolerant corals and analyze their molecular responses. By studying gene expression in coral hosts, algal symbionts, and microbial genes, we aim to guide coral conservation efforts.

Join our next NGS webinar | June 5th at 11:00 CEST.

Register here!

Spotify supports chapters which makes it easier to find nuggets – check it out & rate our podcast if you’re using mobile version!

Supported by the West German Genome Center and Next Generation Sequencing Competence Network, we’re dedicated to discuss genomics & transcriptomics tech in the way YOU could understand 

Recorded at the Multimediazentrum, University of Düsseldorf