This repository holds code and analysis pipeline generated for Wales vaccine safety analysis conducted as part of the DaCVaP collaboration funded by HDRUK. Access the scientific article here Access the supplementary materials including clinical codes from here

This project was conducted in the Trusted Research Envirnment of Wales known as SAIL Databank and been granted approval by Information Governance Panel Review (IGRP) under project number 0911.

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Fatemeh Torabi,Stuart Bedston,Emily Lowthian,Ashley Akbari,Rhiannon K Owen,Declan T Bradley,Utkarsh Agrawal, Peter Collins,Richard Fry,Lucy J Gtiffiths,Jillian Beggs,Gareth Davies,Joe Hollinghurst,Jane Lyons, Hoda Abbasizanjani,Simon Cottrell,Malorie Perry,Richard Roberts,Amaya Azcoaga-Lorenzo,Adeniyi Francis, Ting Shi,Ruby S. M. Tsang,Chris Robertson,Richard Hobbs,Simon de Lusignan,Colin MacCowan,Michael Gravenor, Colin R Simpson,Aziz Sheikh,Lyons Ronan A.

The Statistical Analysis plan of this work is available at SAP. We also made the code and data to reproduce figures available through this repository. Information and meta-data of the main patient-level data sources used in this study are available openly at HDRUK Innovation gateway; however the patient level data sources is only available through the secure analyticail platform of the SAIL Databank at Swansea University, Swansea, UK. All proposals to use SAIL data are subject to review by an independent Information Governance Review Panel (IGRP). Before any data can be accessed, approval must be given by the IGRP. The IGRP gives careful consideration to each project to ensure proper and appropriate use of SAIL data. When access has been granted, it is gained through a privacy protecting safe haven and remote access system referred to as the SAIL Gateway. SAIL has established an application process to be followed by anyone who would like to access data via SAIL applications.

This work uses data provided by patients and collected by the NHS as part of their care and support. We would also like to acknowledge all data providers who make anonymised data available for research.

We wish to acknowledge the collaborative partnership of DaCVaP consortium which led to this output. We also wish to acknowledge the collaboration that enabled acquisition and access to the data, led by the Swansea University Health Data Research UK team under the direction of the Welsh Government Technical Advisory Cell (TAC) and includes the following groups and organisations: the Secure Anonymised Information Linkage (SAIL) Databank, Administrative Data Research (ADR) Wales, NHS Wales Informatics Service (NWIS), Public Health Wales, NHS Shared Services Partnership and the Welsh Ambulance Service Trust (WAST). All research conducted has been completed under the permission and approval of the SAIL independent Information Governance Review Panel (IGRP) project number 0911.

This work was supported by the Medical Research Council [MR/V028367/1]; Health Data Research UK [HDR-9006] which receives its funding from the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust; and Administrative Data Research UK which is funded by the Economic and Social Research Council [grant ES/S007393/1]. This work was supported by the Wales COVID-19 Evidence Centre, funded by Health and Care Research Wales.

This research is part of the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation. We also acknowledge the support of the HDR UK BREATHE Hub, funded by the Industrial Strategy Challenge Fund through a grant via Health Data Research UK.

The work is under peer-review please get in touch for further details and collaboration: [email protected]