ctcae5_grader

ctcae5_grader is a SAS macro package that automates the grading of laboratory tests according to CTCAE v5.0. It standardises grading rules for common laboratory parameters (e.g. haematology, biochemistry, electrolytes) and provides character and numeric grade outputs.

Overview and image of usage

data lab_testcases;
  length PARAMCD $12 AVALU $16;
  infile datalines dsd truncover;
  input PARAMCD :$12. AVAL AVALU :$16. ANRLO ANRHI BASE MFRHI;
  datalines;
HGB,  14.5,g/dL,  12, 13.5, .,   .
HGB,  15.4,g/dL,  12, 14.0, .,   .
HGB,  17.0,g/dL,  12, 12.5, .,   .
HGB,   7.5,g/dL,  12, 13.5, .,   .
ALT,   70,  U/L,   .,  40,   30,  .
ALT,  900,  U/L,   .,  40,   60,  . 
NEUT,  0.8, 10^9/L, 1.5, .,  .,   .
NEUT,  0.45,10^9/L, 1.5, .,  .,   .
;
run;

data lab_checked;
  set lab_testcases;
  %CTCAE5_HGB()
  %CTCAE5_ALT()
  %CTCAE5_NEUT()
run;

`%ctcae5_alb()` macro

Parameters :

  PARAMCD = Variable name (expected "ALB")
  AVAL    = Observed value (Albumin result)
  AVALU   = Unit (expected "g/dL" or "g/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Albumin):

  Units in "g/dL":
    - value < LLN and >= 3.0             -> Grade 1
    - 2.0 <= value < 3.0                 -> Grade 2
    - value < 2.0                       -> Grade 3

  Units in "g/L":
    - value < LLN and >= 30              -> Grade 1
    - 20 <= value < 30                   -> Grade 2
    - value < 20                        -> Grade 3

`%ctcae5_alp()` macro

Parameters :

  PARAMCD = Variable name (expected "ALP")
  AVAL    = Observed value (ALP result, in U/L)
  BASE    = Baseline value
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Alkaline Phosphatase):

  If baseline <= ULN:
    - ULN < value <= 2.5 * ULN          -> Grade 1
    - 2.5 * ULN < value <= 5 * ULN      -> Grade 2
    - 5 * ULN < value <= 20 * ULN       -> Grade 3
    - value > 20 * ULN                 -> Grade 4

  If baseline > ULN:
    - 2 * baseline < value <= 2.5 * baseline   -> Grade 1
    - 2.5 * baseline < value <= 5 * baseline  -> Grade 2
    - 5 * baseline < value <= 20 * baseline   -> Grade 3
    - value > 20 * baseline                  -> Grade 4

`%ctcae5_alt()` macro

Parameters :

  PARAMCD = Variable name (expected "ALT")
  AVAL    = Observed value (ALT result, in U/L)
  BASE    = Baseline value
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Alanine Aminotransferase):

  If baseline <= ULN:
    - ULN < value <= 3 * ULN            -> Grade 1
    - 3 * ULN < value <= 5 * ULN        -> Grade 2
    - 5 * ULN < value <= 20 * ULN       -> Grade 3
    - value > 20 * ULN                 -> Grade 4

  If baseline > ULN:
    - 1.5 * baseline < value <= 3 * baseline   -> Grade 1
    - 3 * baseline < value <= 5 * baseline     -> Grade 2
    - 5 * baseline < value <= 20 * baseline    -> Grade 3
    - value > 20 * baseline                   -> Grade 4

`%ctcae5_aptt()` macro

Parameters :

  PARAMCD = Variable name (expected "APTT")
  AVAL    = Observed value (APTT result, in seconds)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Activated Partial Thromboplastin Time):

  Prolonged (Above ULN)
    - ULN < value <= 1.5 * ULN          -> Grade 1
    - 1.5 * ULN < value <= 2.5 * ULN    -> Grade 2
    - value > 2.5 * ULN                -> Grade 3

`%ctcae5_ast()` macro

Parameters :

  PARAMCD = Variable name (expected "AST")
  AVAL    = Observed value (AST result, in U/L)
  BASE    = Baseline value
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Aspartate Aminotransferase):

  If baseline <= ULN:
    - ULN < value <= 3 * ULN            -> Grade 1
    - 3 * ULN < value <= 5 * ULN        -> Grade 2
    - 5 * ULN < value <= 20 * ULN       -> Grade 3
    - value > 20 * ULN                 -> Grade 4

  If baseline > ULN:
    - 1.5 * baseline < value <= 3 * baseline   -> Grade 1
    - 3 * baseline < value <= 5 * baseline     -> Grade 2
    - 5 * baseline < value <= 20 * baseline    -> Grade 3
    - value > 20 * baseline                   -> Grade 4

`%ctcae5_bili()` macro

Parameters :

  PARAMCD = Variable name (expected "BILI")
  AVAL    = Observed value (Total Bilirubin result, in mg/dL)
  BASE    = Baseline value
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Total Bilirubin):

  If baseline <= ULN:
    - ULN < value <= 1.5 * ULN          -> Grade 1
    - 1.5 * ULN < value <= 3 * ULN      -> Grade 2
    - 3 * ULN < value <= 10 * ULN       -> Grade 3
    - value > 10 * ULN                 -> Grade 4

  If baseline > ULN:
    - baseline < value <= 1.5 * baseline   -> Grade 1
    - 1.5 * baseline < value <= 3 * baseline -> Grade 2
    - 3 * baseline < value <= 10 * baseline -> Grade 3
    - value > 10 * baseline                -> Grade 4

`%ctcae5_ca()` macro

Parameters :

  PARAMCD = Variable name (expected "CA")
  AVAL    = Observed value (Calcium result)
  AVALU   = Unit (expected "mg/dL")
  ANRLO   = Lower limit of normal (LLN)
  ANRHI   = Upper limit of normal (ULN)
  TESTCD  = Lab test code (default "CA")

Grading Criteria (CTCAE v5.0 - Calcium):

  High (Hypercalcemia):
    - ULN < value <= 11.5                -> Grade 1
    - 11.5 < value <= 12.5               -> Grade 2
    - 12.5 < value <= 13.5               -> Grade 3
    - value > 13.5                      -> Grade 4

  Low (Hypocalcemia):
    - value < LLN and <= 8.0             -> Grade 1
    - 7.0 <= value < 8.0                 -> Grade 2
    - 6.0 <= value < 7.0                 -> Grade 3
    - value < 6.0                       -> Grade 4

`%ctcae5_cd4()` macro

Parameters :

  PARAMCD = Variable name (expected "CD4")
  AVAL    = Observed value (CD4+ T-cell count)
  AVALU   = Unit (expected either per volume, e.g., "/mm3", "10^6/L", or "10^9/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - CD4 Count):

  Units in "/mm3", "10^6/L", "/uL", "10^3/mL", "M/L":
    - value < LLN and <= 500              -> Grade 1
    - 200 <= value < 500                  -> Grade 2
    - 50 <= value < 200                   -> Grade 3
    - value < 50                         -> Grade 4

  Units in "10^9/L", "/nL", "10^3/uL", "10^6/mL", "G/L":
    - value < LLN and <= 0.5              -> Grade 1
    - 0.2 <= value < 0.5                  -> Grade 2
    - 0.05 <= value < 0.2                 -> Grade 3
    - value < 0.05                       -> Grade 4

`%ctcae5_chol()` macro

Parameters :

  PARAMCD = Variable name (expected "CHOL")
  AVAL    = Observed value (Cholesterol result)
  AVALU   = Unit (expected "mg/dL" or "mmol/L")
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Cholesterol):

  Units in "mg/dL":
    - ULN < value <= 300                 -> Grade 1
    - 300 < value <= 400                 -> Grade 2
    - 400 < value <= 500                 -> Grade 3
    - value > 500                       -> Grade 4

  Units in "mmol/L":
    - ULN < value <= 7.75                -> Grade 1
    - 7.75 < value <= 10.34              -> Grade 2
    - 10.34 < value <= 12.92             -> Grade 3
    - value > 12.92                     -> Grade 4

`%ctcae5_ck()` macro

Parameters :

  PARAMCD = Variable name (expected "CK")
  AVAL    = Observed value (Creatine Kinase result, in U/L)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Creatine Kinase):

  High (Above ULN)
    - ULN < value <= 2.5 * ULN           -> Grade 1
    - 2.5 * ULN < value <= 5 * ULN       -> Grade 2
    - 5 * ULN < value <= 10 * ULN        -> Grade 3
    - value > 10 * ULN                  -> Grade 4

`%ctcae5_creat()` macro

Parameters :

  PARAMCD = Variable name (expected "CREAT")
  AVAL    = Observed value (Creatinine result, e.g., mg/dL or ・ｽ・ｽmol/L)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Creatinine):

  High (Above ULN)
    - ULN < value <= 1.5 * ULN           -> Grade 1
    - 1.5 * ULN < value <= 3 * ULN       -> Grade 2
    - 3 * ULN < value <= 6 * ULN         -> Grade 3
    - value > 6 * ULN                   -> Grade 4

`%ctcae5_dlco()` macro

Parameters :

  PARAMCD = Variable name (expected "DLCO")
  AVAL    = Observed value (DLCO result)
  AVALU   = Unit (e.g., mL/min/mmHg or % predicted)
  BASE    = Baseline value
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - DLCO):

  Compared with LLN:
    - 0 < (LLN - value) <= 3            -> Grade 1
    - 3 < (LLN - value) <= 5            -> Grade 2
    - 5 < (LLN - value) <= 8            -> Grade 3
    - (LLN - value) > 8                -> Grade 4

  Compared with Baseline:
    - 0 < (Baseline - value) <= 3       -> Grade 1
    - 3 < (Baseline - value) <= 5       -> Grade 2
    - 5 < (Baseline - value) <= 8       -> Grade 3
    - (Baseline - value) > 8           -> Grade 4

`%ctcae5_fev1()` macro

Parameters :

  PARAMCD = Variable name (expected "FEV1")
  AVAL    = Observed value (FEV1 result, % of predicted)
  AVALU   = Unit (expected "%")

Grading Criteria (CTCAE v5.0 - FEV1):

  - 70% <= value <= 99%                  -> Grade 1
  - 60% <= value < 70%                  -> Grade 2
  - 50% <= value < 60%                  -> Grade 3
  - value < 50%                        -> Grade 4

`%ctcae5_fibrinog()` macro

Parameters :

  PARAMCD = Variable name (expected "FIBRINOG")
  AVAL    = Observed value (Fibrinogen result)
  BASE    = Baseline value
  ANRLO   = Lower limit of normal (LLN)
  AVALU   = Unit (expected "mg/dL" or "g/L")

Grading Criteria (CTCAE v5.0 - Fibrinogen):

  If baseline >= LLN:
    - 0.75 * LLN <= value < LLN          -> Grade 1
    - 0.50 * LLN <= value < 0.75 * LLN   -> Grade 2
    - 0.25 * LLN <= value < 0.50 * LLN   -> Grade 3
    - value < 0.25 * LLN                -> Grade 4

  If baseline < LLN (baseline abnormal):
    - decrease <= 0% and > -25%          -> Grade 1
    - -50% < decrease <= -25%            -> Grade 2
    - -75% < decrease <= -50%            -> Grade 3
    - decrease <= -75%                   -> Grade 4

  Absolute threshold:
    - value < 50 mg/dL (or < 0.5 g/L)   -> Grade 4

`%ctcae5_ggt()` macro

Parameters :

  PARAMCD = Variable name (expected "GGT")
  AVAL    = Observed value (GGT result, in U/L)
  BASE    = Baseline value
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Gamma-Glutamyl Transferase):

  If baseline ? ULN:
    - ULN < value <=2.5 * ULN          -> Grade 1
    - 2.5 * ULN < value ? 5 * ULN      -> Grade 2
    - 5 * ULN < value ? 20 * ULN       -> Grade 3
    - value > 20 * ULN                 -> Grade 4

  If baseline > ULN:
    - 2 * baseline < value <= 2.5 * baseline   -> Grade 1
    - 2.5 * baseline < value <= 5 * baseline   -> Grade 2
    - 5 * baseline < value <= 20 * baseline    -> Grade 3
    - value > 20 * baseline                   -> Grade 4

`%ctcae5_gluc()` macro

Parameters :

  PARAMCD = Variable name (expected "GLUC")
  AVAL    = Observed value (Glucose result)
  AVALU   = Unit (expected "mg/dL" or "mmol/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Glucose, Hypoglycemia):

  Units in "mg/dL":
    - value < LLN and ? 55              -> Grade 1
    - 40 <= value < 55                   -> Grade 2
    - 30 <= value < 40                   -> Grade 3
    - value < 30                        -> Grade 4

  Units in "mmol/L":
    - value < LLN and ? 3.0             -> Grade 1
    - 2.2 <= value < 3.0                 -> Grade 2
    - 1.7 <= value < 2.2                 -> Grade 3
    - value < 1.7                       -> Grade 4

`%ctcae5_haptog()` macro

Parameters :

  PARAMCD = Variable name (expected "HAPTOG")
  AVAL    = Observed value (Haptoglobin result)
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Haptoglobin):

  Low (Below LLN)
    - value < LLN                      -> Grade 1

`%ctcae5_hco3()` macro

Parameters :

  PARAMCD = Variable name (expected "HCO3")
  AVAL    = Observed value (Bicarbonate result)
  AVALU   = Unit (expected "mmol/L")
  ANRHI   = Upper limit of normal (ULN)
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Bicarbonate):

  Low (Below LLN)
    - value < LLN                      -> Grade 1

`%ctcae5_hgb()` macro

Parameters :

  PARAMCD = Variable name (expected "HGB")
  AVAL    = Observed value (Hemoglobin result)
  AVALU   = Unit (expected "g/dL")
  ANRHI   = Upper limit of normal (ULN)
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Hemoglobin):

  High (Above ULN)
    - ULN < value <= ULN+2 g/dL         ->Grade 1
    - ULN+2 < value <= ULN+4 g/dL       ->Grade 2
    - value > ULN+4 g/dL               ->Grade 3

  Low (Below LLN)
    - 10 g/dL <= value < LLN            ->Grade 1
    - 8 g/dL <= value < 10 g/dL         ->Grade 2
    - value < 8 g/dL                   ->Grade 3

`%ctcae5_k()` macro

Parameters :

  PARAMCD = Variable name (expected "K")
  AVAL    = Observed value (Potassium result)
  AVALU   = Unit (expected "mmol/L")
  ANRLO   = Lower limit of normal (LLN)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Potassium):

  High (Hyperkalemia):
    - ULN < value <= 5.5                 -> Grade 1
    - 5.5 < value <= 6.0                 -> Grade 2
    - 6.0 < value <= 7.0                 -> Grade 3
    - value > 7.0                       -> Grade 4

  Low (Hypokalemia):
    - value < LLN and <= 3.0             -> Grade 2
    - 2.5 <= value < 3.0                 -> Grade 3
    - value < 2.5                       -> Grade 4

`%ctcae5_ldh()` macro

Parameters :

  PARAMCD = Variable name (expected "LDH")
  AVAL    = Observed value (LDH result, in U/L)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Lactate Dehydrogenase):

  High (Above ULN)
    - value > ULN                      -> Grade 1

`%ctcae5_lvef()` macro

Parameters :

  PARAMCD = Variable name (expected "LVEF")
  AVAL    = Observed value (Left Ventricular Ejection Fraction, in %)
  AVALU   = Unit (expected "%")
  BASE    = Baseline value (in %)

Grading Criteria (CTCAE v5.0 - LVEF):

  Absolute value:
    - 40% <= value < 50%                 -> Grade 2
    - 20% <= value < 40%                 -> Grade 3
    - value < 20%                       -> Grade 4

  Drop from baseline:
    - 10% <= decrease < 20%              -> Grade 2
    - decrease >= 20%                    -> Grade 3

`%ctcae5_lym()` macro

Parameters :

  PARAMCD = Variable name (expected "LYM")
  AVAL    = Observed value (Lymphocyte count)
  AVALU   = Unit (expected either per volume, e.g., "/mm3", "/uL" or "10^9/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Lymphocytes):

  High (Above ULN):
    Units in "/mm3", "/uL":
      - 4000 < value <= 20000            -> Grade 2
      - value > 20000                   -> Grade 3

    Units in "10^9/L":
      - 4 < value <= 20                  -> Grade 2
      - value > 20                      -> Grade 3

  Low (Below LLN):
    Units in "/mm3", "/uL":
      - value < LLN and <= 800           -> Grade 1
      - 500 <= value < 800               -> Grade 2
      - 200 <= value < 500               -> Grade 3
      - value < 200                     -> Grade 4

    Units in "10^9/L":
      - value < LLN and <= 0.8           -> Grade 1
      - 0.5 <= value < 0.8               -> Grade 2
      - 0.2 <= value < 0.5               -> Grade 3
      - value < 0.2                     -> Grade 4

`%ctcae5_mg()` macro

Parameters :

  PARAMCD = Variable name (expected "MG")
  AVAL    = Observed value (Magnesium result)
  AVALU   = Unit (expected "mg/dL")
  ANRLO   = Lower limit of normal (LLN)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Magnesium):

  High (Hypermagnesemia):
    - ULN < value <= 3.0                 -> Grade 1
    - 3.0 < value <= 8.0                 -> Grade 3
    - value > 8.0                       -> Grade 4

  Low (Hypomagnesemia):
    - value < LLN and <= 1.2             -> Grade 1
    - 0.9 <= value < 1.2                 -> Grade 2
    - 0.7 <= value < 0.9                 -> Grade 3
    - value < 0.7                       -> Grade 4

`%ctcae5_na()` macro

Parameters :

  PARAMCD = Variable name (expected "NA")
  AVAL    = Observed value (Sodium result)
  AVALU   = Unit (expected "mmol/L")
  ANRLO   = Lower limit of normal (LLN)
  ANRHI   = Upper limit of normal (ULN)

Grading Criteria (CTCAE v5.0 - Sodium):

  High (Hypernatremia):
    - ULN < value <= 150                 -> Grade 1
    - 150 < value <= 155                 -> Grade 2
    - 155 < value <= 160                 -> Grade 3
    - value > 160                       -> Grade 4

  Low (Hyponatremia):
    - value < LLN and >= 130             -> Grade 1
    - 125 <= value <= 129                 -> Grade 2
    - 120 <= value <= 124                 -> Grade 3
    - value < 120                       -> Grade 4

`%ctcae5_neut()` macro

Parameters :

  PARAMCD = Variable name (expected "NEUT")
  AVAL    = Observed value (Neutrophil count)
  AVALU   = Unit (expected either per volume, e.g., "/mm3", "/uL" or "10^9/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Neutrophils):

  Units in "/mm3", "/uL":
    - value < LLN and <= 1500            -> Grade 1
    - 1000 <= value < 1500               -> Grade 2
    - 500 <= value < 1000                -> Grade 3
    - value < 500                       -> Grade 4

  Units in "10^9/L":
    - value < LLN and >= 1.5             -> Grade 1
    - 1.0 <= value < 1.5                 -> Grade 2
    - 0.5 <= value < 1.0                 -> Grade 3
    - value < 0.5                       -> Grade 4

`%ctcae5_plat()` macro

Parameters :

  PARAMCD = Variable name (expected "PLAT")
  AVAL    = Observed value (Platelet count)
  AVALU   = Unit (expected either per volume, e.g., "/mm3", "/uL" or "10^9/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - Platelets):

  Units in "/mm3", "/uL":
    - value < LLN and >= 75,000          -> Grade 1
    - 50,000 <= value < 75,000           -> Grade 2
    - 25,000 <= value < 50,000           -> Grade 3
    - value < 25,000                    -> Grade 4

  Units in "10^9/L":
    - value < LLN and >= 75              -> Grade 1
    - 50 <= value < 75                   -> Grade 2
    - 25 <= value < 50                   -> Grade 3
    - value < 25                        -> Grade 4

`%ctcae5_qtcf()` macro

Parameters :

  PARAMCD = Variable name (expected "QTCF")
  AVAL    = Observed value (QTcF interval, in milliseconds)
  AVALU   = Unit (expected "ms")
  BASE    = Baseline value (in ms)

Grading Criteria (CTCAE v5.0 - QTcF Interval):

  Absolute value:
    - 450 ms <= value <= 480 ms           -> Grade 1
    - 480 ms < value <= 500 ms           -> Grade 2
    - value > 500 ms                    -> Grade 3

  Change from baseline:
    - 30 ms <= increase < 60 ms          -> Grade 1
    - increase >= 60 ms                  -> Grade 2

`%ctcae5_tni()` macro

Parameters :

  PARAMCD = Variable name (expected "TNI")
  AVAL    = Observed value (Troponin I result, e.g., ng/mL)
  ANRHI   = Upper limit of normal (ULN)
  MFRHI   = Medical decision limit (e.g., myocardial infarction reference high)

Grading Criteria (CTCAE v5.0 - Troponin I):

  If MFRHI is not provided:
    - value > ULN                      -> Grade 1

  If MFRHI is provided:
    - ULN < value < MFRHI              -> Grade 1
    - value <= MFRHI                    -> Grade 3

`%ctcae5_trig()` macro

Parameters :

  PARAMCD = Variable name (expected "TRIG")
  AVAL    = Observed value (Triglycerides result)
  AVALU   = Unit (expected "mg/dL" or "mmol/L")

Grading Criteria (CTCAE v5.0 - Triglycerides):

  Units in "mg/dL":
    - 150 <= value <= 300                 -> Grade 1
    - 300 < value <= 500                 -> Grade 2
    - 500 < value <= 1000                -> Grade 3
    - value > 1000                      -> Grade 4

  Units in "mmol/L":
    - 1.71 <= value <= 3.42               -> Grade 1
    - 3.42 <= value <= 5.7                -> Grade 2
    - 5.7 < value <= 11.4                -> Grade 3
    - value > 11.4                      -> Grade 4

`%ctcae5_tropnt()` macro

Parameters :

  PARAMCD = Variable name (expected "TROPNT")
  AVAL    = Observed value (Troponin T result, e.g., ng/mL)
  ANRHI   = Upper limit of normal (ULN)
  MFRHI   = Medical decision limit (e.g., myocardial infarction reference high)

Grading Criteria (CTCAE v5.0 - Troponin T):

  If MFRHI is not provided:
    - value > ULN                      -> Grade 1

  If MFRHI is provided:
    - ULN < value < MFRHI              -> Grade 1
    - value <= MFRHI                    -> Grade 3

`%ctcae5_wbc()` macro

Parameters :

  PARAMCD = Variable name (expected "WBC")
  AVAL    = Observed value (White Blood Cell count)
  AVALU   = Unit (expected either per volume, e.g., "/mm3", "/uL" or "10^9/L")
  ANRLO   = Lower limit of normal (LLN)

Grading Criteria (CTCAE v5.0 - White Blood Cells):

  High (Leukocytosis):
    Units in "/mm3", "/uL":
      - value > 100,000                 -> Grade 3

    Units in "10^9/L":
      - value > 100                     -> Grade 3

  Low (Leukopenia):
    Units in "/mm3", "/uL":
      - value < LLN and ? 3000          -> Grade 1
      - 2000 <= value < 3000             -> Grade 2
      - 1000 <= value < 2000             -> Grade 3
      - value < 1000                    -> Grade 4

    Units in "10^9/L":
      - value < LLN and ? 3.0           -> Grade 1
      - 2.0 <= value < 3.0               -> Grade 2
      - 1.0 <= value < 2.0               -> Grade 3
      - value < 1.0                     -> Grade 4

version history

0.1.0(21August2025): Initial version

What is SAS Packages?

The package is built on top of SAS Packages Framework(SPF) developed by Bartosz Jablonski.

For more information about the framework, see SAS Packages Framework.

You can also find more SAS Packages (SASPacs) in the SAS Packages Archive(SASPAC).

How to use SAS Packages? (quick start)

1. Set-up SAS Packages Framework

First, create a directory for your packages and assign a packages fileref to it.

filename packages "\path\to\your\packages";

Secondly, enable the SAS Packages Framework. (If you don't have SAS Packages Framework installed, follow the instruction in SPF documentation to install SAS Packages Framework.)

%include packages(SPFinit.sas)

2. Install SAS package

Install SAS package you want to use with the SPF's %installPackage() macro.

For packages located in SAS Packages Archive(SASPAC) run:
```
%installPackage(packageName)
```

For packages located in PharmaForest run:

%installPackage(packageName, mirror=PharmaForest)

For packages located at some network location run:
```
%installPackage(packageName, sourcePath=https://some/internet/location/for/packages)
```
(e.g. %installPackage(ABC, sourcePath=https://github.com/SomeRepo/ABC/raw/main/))

3. Load SAS package

Load SAS package you want to use with the SPF's %loadPackage() macro.

%loadPackage(packageName)

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ctcae5_grader		ctcae5_grader
hist		hist
LICENSE		LICENSE
README.md		README.md
ctcae5_grader.md		ctcae5_grader.md
ctcae5_grader.png		ctcae5_grader.png
ctcae5_grader.zip		ctcae5_grader.zip
ctcae5_grader_small.png		ctcae5_grader_small.png
description.sas		description.sas
license.sas		license.sas

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ctcae5_grader

Overview and image of usage

%ctcae5_alb() macro

%ctcae5_alp() macro

%ctcae5_alt() macro

%ctcae5_aptt() macro

%ctcae5_ast() macro

%ctcae5_bili() macro

%ctcae5_ca() macro

%ctcae5_cd4() macro

%ctcae5_chol() macro

%ctcae5_ck() macro

%ctcae5_creat() macro

%ctcae5_dlco() macro

%ctcae5_fev1() macro

%ctcae5_fibrinog() macro

%ctcae5_ggt() macro

%ctcae5_gluc() macro

%ctcae5_haptog() macro

%ctcae5_hco3() macro

%ctcae5_hgb() macro

%ctcae5_k() macro

%ctcae5_ldh() macro

%ctcae5_lvef() macro

%ctcae5_lym() macro

%ctcae5_mg() macro

%ctcae5_na() macro

%ctcae5_neut() macro

%ctcae5_plat() macro

%ctcae5_qtcf() macro

%ctcae5_tni() macro

%ctcae5_trig() macro

%ctcae5_tropnt() macro

%ctcae5_wbc() macro

version history

What is SAS Packages?

How to use SAS Packages? (quick start)

1. Set-up SAS Packages Framework

2. Install SAS package

3. Load SAS package

Enjoy!

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`%ctcae5_alb()` macro

`%ctcae5_alp()` macro

`%ctcae5_alt()` macro

`%ctcae5_aptt()` macro

`%ctcae5_ast()` macro

`%ctcae5_bili()` macro

`%ctcae5_ca()` macro

`%ctcae5_cd4()` macro

`%ctcae5_chol()` macro

`%ctcae5_ck()` macro

`%ctcae5_creat()` macro

`%ctcae5_dlco()` macro

`%ctcae5_fev1()` macro

`%ctcae5_fibrinog()` macro

`%ctcae5_ggt()` macro

`%ctcae5_gluc()` macro

`%ctcae5_haptog()` macro

`%ctcae5_hco3()` macro

`%ctcae5_hgb()` macro

`%ctcae5_k()` macro

`%ctcae5_ldh()` macro

`%ctcae5_lvef()` macro

`%ctcae5_lym()` macro

`%ctcae5_mg()` macro

`%ctcae5_na()` macro

`%ctcae5_neut()` macro

`%ctcae5_plat()` macro

`%ctcae5_qtcf()` macro

`%ctcae5_tni()` macro

`%ctcae5_trig()` macro

`%ctcae5_tropnt()` macro

`%ctcae5_wbc()` macro

Packages