This workshop will teach you the biology behind proteomics, how to conduct proteomic analysis, and how to associate them with both phenotypic and genetic outcomes.

This workshop was constructed in R 4.5.1 and RStudio 2025.05.1+513 This workshop is considered an advanced workshop where participants should understand the basics in R, how to install and use basic packages, and troubleshoot basic code.

• R
• RStudio
• PLINK 1.9

• Intro to Proteomics

  • Aptamer vs. Antibody Proteomics
  • Somalogic Data Processing
  • Olink Data Processing

• Association Testing and Multiplexing

  • Association Testing
  • Mutiple Comparison Correction

• pQTLs

  • Cis and Trans pQTLs

• Conclusion

This work is the second interation of a previous workshop sponsored by Somalogic The example Somalogic data was provided by Somalogic through their github https://github.com/SomaLogic/SomaLogic-Data The example Olink data was provided by Dube, Marie-Pierre Dube, Marie-Pierre (2023). Raw Olink data. figshare. Dataset. https://doi.org/10.6084/m9.figshare.22811915.v1 Workshop created as part of the McGill Initiative in Computational Medicine