I am a Junior Group Leader at the Institute for Virology in Freiburg. We focus on viral genomics and intra-host evolution of diverse pathogens (Hepatitis E virus, SARS-CoV-2, Influenza A, MPXV and HSV-1). I started bioinformatics at the beginning of the SARS-CoV-2 pandemic and have been in love with big data, genomics, metagenomics, coding and pyhlogenetics ever since. I am a super weird mixture of wet-lab molecular virologist, bioinformatician, data scientist, NGS specialist, epidemiologist, clinical scientist and nerd.

I am working on software for viral genomics. Available through pip and conda.

• BAMdash Aggregate your virus sequencing results into an interactive plot.
• varVAMP Design primers for PCR on highly variable alignments.
• virHEAT Compare vcf files as a heatmap.
• MSAexplorer Multiple Sequence Alignment graphing library on top of matplotlib.

• Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants

• Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

• Antibody escape and global spread of SARS-CoV-2 lineage A. 27

• Evolution and antiviral specificities of interferon-induced Mx proteins of bats against Ebola, influenza, and other RNA viruses

• The landscape of SARS-CoV-2 RNA modifications

• Comparative Study of Ten Thogotovirus Isolates and Their Distinct In Vivo Characteristics

• Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein

• Case series: convalescent plasma therapy for patients with COVID-19 and primary antibody deficiency

  ... Full list of publications