ToniFlin is an Android-based application designed to calculate and adjust ingredient levels in parenteral formulations to achieve isotonicity.
It implements the cryoscopic method, allowing users to correct hypertonic or hypotonic solutions quickly and accurately.
This software provides a simple and accessible tool for pharmaceutical education, training, and research purposes.
- Cryoscopic-based tonicity adjustment for single or multi-component formulations
- Flexible ingredient modification to achieve isotonicity
- Interactive interface for fast data entry and visualization
- Offline functionality – no internet required after installation
- Educational tool for pharmacy students and researchers
- Clone this repository:
git clone https://github.com/KHRZ1/toniflin.git
- Open the project in Android Studio.
- Allow Gradle to sync and build.
- Run the app on an emulator or connected Android device.
Launch ToniFlin on your Android device. Enter the desired parenteral formulation components. Adjust ingredient concentrations using the cryoscopic-based calculator. View the recommended isotonic composition for your solution. The app assists in comparing multiple formulations and understanding how solute concentration affects osmotic balance.\
For a full mathematical explanation of the adjustment equation, see the section “Mathematical Basis for Isotonic Adjustment” in the accompanying paper.md file.
Accurate isotonicity adjustment is a fundamental aspect of parenteral formulation design, yet the necessary calculations are often time-consuming and error-prone when done manually. ToniFlin provides a practical digital implementation of the cryoscopic method, simplifying isotonicity computation while maintaining precision, accessibility, and educational value.
This project is licensed under the MIT License — see the LICENSE file for details.
If you use this software, please cite it as: Umar AK, et al. ToniFlin: Android-based isotonicity adjustment calculator using the cryoscopic method. Journal of Open Source Software, 2025.
@article{Umar2025, author = {Abd. Kakhar Umar and coauthors}, title = {ToniFlin: Android-based isotonicity adjustment calculator using the cryoscopic method}, journal = {Journal of Open Source Software}, year = {2025}, doi = {10.xxxx/joss.xxxxx} }
Abd. Kakhar Umar Medical Informatics Laboratory, ETFLIN GitHub: @KHRZ1
The development of ToniFlin was inspired by the need for a practical educational tool for isotonicity adjustment, based on the Kahar method and established cryoscopic calculation principles.